|
KMID : 1145520190050010061
|
|
Journal of Radiopharmaceuticals and Molecular Probes
2019 Volume.5 No. 1 p.61 ~ p.68
|
|
|
Synthesis and evaluation of metal purine-type complexes for lung cancer imaging
|
|
Kang Kyeung-Jun
Ko In-Ok
Park Ji-Ae
Kim Jung-Young
|
|
|
Abstract
|
|
|
|
Purine type compounds has been recently reported to cause the death for lung cancer cell, related to microtubules-targeting agents (MTAs). Therefore it can be used to develop as theranostic radiopharmceuticals in nuclear medicine or gadolinium-based MRI imaging agents by chelate chemistry. In the study, we tried to chemically bind a DOTA chelate on the end of purine compound and obtained a specific conjugate of DOTApurine for metal coordination. In particular, radiometal like Cu-64, for the development of MRI imaging agents, can be utilized to choice good candidates before the synthesis of gadolinium complexes. By the screening of radioisotope technique, Gd-DOTA-purine type complex was successfully prepared and showed MRI imaging for lung cancer cell into the mouse model.
|
|
|
KEYWORD
|
|
|
Purine, Lung cancer, Cu-64, Gd, PET/MRI
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|